Herpes Simplex Virus

HSV encephalitis during acyclovir therapy reported in premature infant

Published in TB and Outbreaks Week, May 10th, 2005

Herpes simplex virus (HSV) encephalitis developing during acyclovir therapy has been reported in premature infant.

According to a case report in the journal Pediatrics, cutaneous HSV-2 infection "was recognized at 19 days of age in a 1,415-g female infant born at 31 weeks of gestation."

"Cerebrospinal fluid (CSF) HSV polymerase chain reaction (PCR) was negative, and MRI of the brain was normal," noted M. Fonseca-Aten and coauthors at the University of Texas. "After a 14-day course of high-dose intravenous acyclovir, the infant developed a cutaneous recurrence at 38 days of age."

"CSF HSV PCR again was negative. She was...

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Source: TB and Outbreaks Week (2005-05-10)

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