Mycobacterium Tuberculosis
MTB evades host antimicrobial defenses by inhibiting phagosome maturation
Published in TB and Outbreaks Week, May 10th, 2005
According to recent research published in the journal Clinical Immunology, "Tuberculosis is one of the world's most devastating diseases, with more than two million deaths and eight million new cases occurring annually.
"Mycobacterium tuberculosis evades the innate antimicrobial defenses of macrophages by inhibiting the maturation of its phagosome to a bactericidal phagolysosome."
"Phagosome maturation is dependent on macrophage Ca2+ signaling, which results in the recruitment of cytosolic calmodulin (CaM) to...
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