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Anti-Infectives

Ramoplanin is highly active against drug-resistant C. difficile in vitro

Published in TB and Outbreaks Week, May 10th, 2005

The glycopeptide antibiotic ramoplanin is highly active against drug-resistant Clostridium difficile in vitro.

In a study from Spain, scientists evaluated the antimicrobial efficacy of ramoplanin - which "inhibits cell wall synthesis by acting at the level of lipid intermediate formation" - in C. difficile cultures.

"We included strains with reduced susceptibilities to vancomycin (vancomycin-intermediate [Vani] strains) or with resistance to metronidazole (Mtzr), in order to assess the potential utility of ramoplanin for the treatment of C. difficile-associated diarrhea," explained T. Pelaez and coauthors at...

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