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Mycobacteria

Carbon-limited M bovis BCG cells subject to growth rate-dependent control

Published in TB and Outbreaks Week, May 17th, 2005

Carbon-limited Mycobacterium bovis BCG cells are subject to growth rate-dependent control of ribosome biosynthesis and lipid metabolism.

"An experimental system of Mycobacterium tuberculosis growth in a carbon-limited chemostat has been established by the use of Mycobacterium bovis BCG as a model organism. For this model, carbon-limited chemostats with low concentrations of glycerol were used to simulate possible growth rates during different stages of tuberculosis," researchers in England report.

"A doubling time of 23 hours (D=0.03 h-1) was adopted to represent cells during the acute phase of infection, whereas a...

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