Mycobacteria
Polyketide synthases generate complex lipids in mycobacteria
Published in TB and Outbreaks Week, May 24th, 2005
According to scientists in India, "Mycobacterium tuberculosis cell envelope is a treasure house of biologically active lipids of fascinating molecular architecture.
"Although genetic studies have alluded to an array of genes in biosynthesis of complex lipids, their mechanistic, structural, and biochemical principles have not been investigated."
"Here, we have dissected the molecular logic underlying the biosynthesis of a virulence lipid phthiocerol dimycocerosate (PDIM).
"Cell-free reconstitution studies demonstrate that polyketide synthases,...
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