T-Cell Large Granular Lymphocyte Leukemia
Epitope defined for HTLV env seroreactivity observed in LGL leukemia
Published in TB and Outbreaks Week, May 24th, 2005
According to a study from the United States, "T-cell large granular lymphocyte (T-LGL) leukemia is a rare chronic lymphoproliferative disorder of unknown etiology. We have previously reported that patients with T-LGL leukemia were seroreactive against BA21, a 34 amino acid peptide derived from HTLV-I envelope protein p2l.
"We tested sera from 70 patients with T-LGL leukemia and found that 21/70 (30%) of them were seroreactive against fusion peptide GST-BA21. In control group of healthy blood donors 3/30 (10%) were seroreactive."
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