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Leprosy

Microbes lead scientists to immune discovery

Published in TB and Outbreaks Week, June 21st, 2005

With the unusual opportunity that human leprosy infections provide for study of human immune responses, scientists have discovered how the body's early warning system prompts a rapid immune response by two separate armies of defensive cells. The finding helps explain why, when threatened by microbes like the leprosy bug, this initial defense sometimes succeeds in limiting the damage, but in other cases yields to a dangerous, spreading infection.

Led by Stephan R. Krutzik of UCLA, a team of scientists that includes Barry R. Bloom, dean of the Harvard School of Public Health, reported the work in Nature Medicine.

The researchers isolated immune...

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