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DNA Research

Treponemal DNA not preserved in bone

Published in TB and Outbreaks Week, June 28th, 2005

Treponemal DNA is not preserved in bone.

In a recent report, researchers in England conducted a study "to determine whether ancient DNA (aDNA) can be used to study the palaeopathology of venereal syphilis, we carried out a comprehensive analysis of the preservation of human and pathogen DNA in a set of 46 bones of various ages, most of which displayed osteological indications of the disease. Bones came from seven English cemetery sites that were in use during the 9th-19th centuries."

"Twelve of the 46 bones consistently yielded mitochondrial DNA (mtDNA) sequences after replicate polymerase chain reactions (PCRs), and a further 13 bones yielded mtDNA...

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