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Kaposi Sarcoma-Associated Herpesvirus

High incidence of KSHV infection in HIV-related lymphoproliferative disorders

Published in TB and Outbreaks Week, July 5th, 2005

There is a high incidence of Kaposi's sarcoma-associated herpesvirus infection in HIV-related lymphoproliferative disorders.

According to recent research from the Netherlands, "Kaposi sarcoma-associated herpesvirus (KSHV) is known to be associated with two distinct lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD)/MCD-associated plasmablastic lymphoma.

"We here report a high incidence of KSHV infection in solid HIV-associated immunoblastic/plasmablastic non-Hodgkin's lymphomas (NHLs) in patients lacking effusions and without evidence of (prior) MCD."

"Within a cohort of 99...

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