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Malaria Therapy

Artesunate improves efficacy of sulfadoxine-pyrimethamine treatment

Published in TB and Outbreaks Week, July 5th, 2005

The addition of artesunate improves the antimalarial efficacy of sulfadoxine-pyrimethamine therapy.

"To assist the Peruvian Ministry of Health in modifying the malaria treatment policy for their north Pacific coastal region," scientists there "conducted an in vivo efficacy trial of sulfadoxine-pyrimethamine (SP) and SP plus artesunate (SP-AS) for the treatment for uncomplicated Plasmodium falciparium infections."

"A total of 197 patients were randomized to therapy with either SP (25 mg/kg of the sulfadoxine component in a single dose on day 0) or a combination of SP plus AS (4 mg/kg on days 0, 1, and 2), and were followed for 28 days for...

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