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Mycobacterium Tuberculosis

Adenylate cyclase proteins expressed simultaneously in MTB & M. leprae

Published in TB and Outbreaks Week, July 5th, 2005

Multiple adenylate cyclase proteins may be expressed simultaneously in Mycobacterium tuberculosis and Mycobacterium leprae.

According to a study from India, "Analysis of the genome sequence of Mycobacterium tuberculosis H37Rv has identified 16 genes that are similar to the mammalian adenylate and guanylate cyclases.

"Rv1647 was predicted to be an active adenylate cyclase but its position in a phylogenetically distant branch from the other enzymes characterized so far from M. tuberculosis makes it an interestingly divergent nucleotide cyclase to study."

"In agreement with its divergence at the sequence...

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