Published in TB and Outbreaks Week, July 12th, 2005
"In spite of ongoing annual vaccination programs, the seasonal influenza epidemics remain a major cause of high morbidity and mortality. The currently used 'inactivated' vaccines provide very short-term and highly specific humoral immunity due to the frequent antigenic variations in the influenza virion. These intramuscularly administered vaccines also fail to induce protective mucosal immunity at the portal of viral entry and destruction of the virally infected cells by induction of cytotoxic T lymphocytes. Therefore,...
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