Malaria

Domain II from P. vivax ectoplasmic region plays critical role in invasion

Published in TB and Outbreaks Week, July 12th, 2005

Domain II from the Plasmodium vivax ectoplasmic region plays a critical role in receptor binding during cell invasion.

According to published research from France, "Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine candidate. The protein is essential for host-cell invasion, but its molecular function is unknown.

"The crystal structure of the three domains comprising the ectoplasmic region of the antigen from P. vivax, solved at 1.8 angstrom resolution, shows that domains I and II belong to the PAN motif, which defines a superfamily of protein folds implicated in receptor binding."

"We also mapped...

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Source: TB and Outbreaks Week (2005-07-12)

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