Published in TB and Outbreaks Week, July 12th, 2005
"Recent evidence suggests that pregnancy-associated malaria (PAM), associated with maternal anemia and low birth weight, results from preferential sequestration of parasitized red blood cells (pRBC) in the placenta via binding of variant surface antigens (VSA) expressed on the surface of pRBC to chondroitin sulfate A (CSA). The VSA-mediating CSA binding (VSACSA ) and thus sequestration of pRBC in the placenta are antigenically distinct from those that mediate pRBC sequestration...
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