Mycobacterium Tuberculosis
HemZ is essential for heme biosynthesis in Mycobacterium tuberculosis
Published in TB and Outbreaks Week, July 19th, 2005
According to recent research published in the journal Tuberculosis, "The complete sequence and subsequent annotation of the Mycobocterium tuberculosis genome has allowed the, prediction of many genes and gene functions by homology.
"HemZ is a predicted ferrochelatase which ties in an apparent operon with two genes involved in mycolic, acid biosynthesis, mabA and inhA."
"We tried to construct hemZ deletion mutants in M. tuberculosis using a two-step recombination strategy, but could only delete the chromosomal copy when we provided a...
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