HIV/AIDS Pathogenesis

Studies add new findings to HIV/AIDS pathogenesis body of knowledge

Published in TB and Outbreaks Week, July 26th, 2005

New findings from the United States and France describe advances in HIV/AIDS pathogenesis.

Study 1: The mannose receptor is a potential intracellular target of HIV-1 Nef.

According to a study from the United States, "Human immunodeficiency virus (HIV) has derived a variety of means to evade the host immune response. HIV-derived proteins, including Tat, Nef, and Env, have all been reported to decrease expression of host molecules such as CD4 and major histocompatibility complex I, which would assist in limiting viral replication.

"The mannose receptor (MR) on the surface of macrophages and dendritic cells (DC) has been proposed to...

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Source: TB and Outbreaks Week (2005-07-26)

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