Mycobacterium Tuberculosis
CREB positively regulates IFN-gamma production by T cells that respond to MTB
Published in TB and Outbreaks Week, August 2nd, 2005
"IFN-gamma is essential for resistance to many intracellular pathogens, including Mycobacterium tuberculosis. Transcription of the IFN-gamma gene in activated T cells is controlled by the proximal promoter element (-73 to -48 bp)," scientists in the United States report.
"Cyclic AMP response element-binding protein (CREB) binds to the IFN-gamma proximal promoter and binding is enhanced by phosphorylation of CREB. Studies in human T cell lines and in transgenic mice have yielded conflicting...
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