Papillomavirus
DNA methylation may force HPVs into latency with repressed transcription
Published in TB and Outbreaks Week, August 2nd, 2005
"Intra-anal malignancies disproportionately affect individuals who engage in anal intercourse because of infection with human papillomaviruses (HPVs), with an increased risk attributed to infection with HIV because of a declining immunity against HPVs.
"Long-term persistence of HPVs suggests yet other mechanisms that determine the clinical outcome, however," wrote investigators in the Journal of Acquired Immune Deficiency Syndromes.
"Because methylation of HPV DNA represses oncogene expression in cervical samples," said the authors,...
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