Tuberculosis
Rv3676 gene implicated in reactivation of dormant M. tuberculosis infections
Published in TB and Outbreaks Week, August 2nd, 2005
"Deletion of gene Rv3676 in Mycobacterium tuberculosis coding for a transcription factor belonging to the cAMP receptor protein (CRP) family caused growth defects in laboratory medium, in bone marrow-derived macrophages and in a mouse model of tuberculosis.
"Transcript profiling of M. tuberculosis grown in vitro identified 16 genes with significantly altered expression in the mutant compared with the wild type," investigators in England report.
"Analysis of the DNA sequences upstream of the corresponding open reading...
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