Epstein-Barr Virus
EBV infection induces expression of the ATF-2/c-Jun in B but not B-CLL cells
Published in TB and Outbreaks Week, August 9th, 2005
"B cell type chronic lymphocytic leukaemia (B-CLL) cells carry the Epstein-Barr virus (EBV) receptor CD21 and can be infected in vitro with the virus. The infected cells exhibit an unusual EBV program, they express the nuclear proteins but not latent membrane protein 1 (LMP-1).
"Similar cells were encountered in lymphoid tissues of infectious mononucleosis (IM) patients and in lymphoproliferations of immunosuppressed patients," wrote investigators in Sweden.
"EBV infected B-CLL cells can be regarded as model for this...
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