HIV/AIDS Transmission

Incorporation of ABO antigens by HIV-1 may affect viral transmission

Published in TB and Outbreaks Week, August 23rd, 2005

Incorporation of ABO antigens by HIV-1 may affect viral transmission.

According to a study from England, "ABO histo-blood group antigens have been postulated to modify pathogen spread through the action of natural antibodies and complement. The antigens are generated by a polymorphic glycosyltransferase encoded by 2 dominant active and a recessive inactive allele."

"In this study we investigated whether ABO sugars are incorporated into the envelope of HIV-1 virions. HIV vectors derived from cells expressing ABO antigens displayed sensitivity to fresh human serum analogous to ABO incompatibility, and ABO histo-blood group sugars were detected on the...

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Source: TB and Outbreaks Week (2005-08-23)

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