Mycobacterium Tuberculosis

Pyrosequencing assay rapidly detects rifampin-resistant M. tuberculosis

Published in TB and Outbreaks Week, August 23rd, 2005

A pyrosequencing assay rapidly detects rifampin-resistant Mycobacterium tuberculosis.

"Rifampin resistance in Mycobacterium tuberculosis could be determined within 2 hours by using pyrosequencing-based approach," scientists in People's Republic of China report.

"Pyrosequencing results of rifampin-resistant (n=21) and rifampin-susceptible (n=20) M. tuberculosis isolates were concordant with those based on drug susceptibility testing and conventional DNA sequencing," wrote J.R. Zhao and colleagues at the Fourth Military Medical University in Xian.

The authors concluded, "Results showed pyrosequencing-based...

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Source: TB and Outbreaks Week (2005-08-23)

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