Tuberculosis

Differential regulation of local immune response crucial for containment of MTB

Published in TB and Outbreaks Week, August 23rd, 2005

The differential regulation of the local immune response is crucial for the containment of Mycobacterium tuberculosis

"In 90% of all cases, Mycobacterium tuberculosis infection results in latency rather than active disease, with the pathogen being contained within granulomatous lesions at the site of primary infection.

"Failure of this containment leads to reactivation of postprimary tuberculosis (TB). The regional immune processes that sustain the delicate balance with persistent M. tuberculosis, however, remain unclear," researchers in Germany report.

"We compared activation statuses, biological functions,...

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Source: TB and Outbreaks Week (2005-08-23)

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