Mycobacterium Tuberculosis Pathogenesis
Primary type II alveolar cells present microbial Ags to Ag-specific CD4+ cells
Published in TB and Outbreaks Week, September 13th, 2005
"Type II alveolar epithelial cells (AEC) can produce various antimicrobial and proinflammatory effector molecules. This, together with their abundance and strategic location, suggests a role in host defense against pulmonary pathogens," scientists writing in the American Journal of Physiology - Lung Cellular and Molecular Physiology report.
"We report that murine type II AEC, like their human counterparts, express class II major histocompatibility complex (MHC). Using a murine model of pulmonary tuberculosis, we find that type II AEC become activated and...
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