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Ebola Fever

Effects of Ebola virus glycoproteins on endothelial cell activation outlined

Published in TB and Outbreaks Week, September 20th, 2005

Researchers outline the effects of Ebola virus glycoproteins on endothelial cell activation and barrier function in a recent issue of the Journal of Virology.

According to a study from Canada and Germany, "Ebola virus causes severe hemorrhagic fever with high mortality rates in humans and nonhuman primates. Vascular instability and dysregulation are disease-decisive symptoms during severe infection. While the transmembrane glycoprotein GP1,2 has been shown to cause endothelial cell destruction, the role of the soluble glycoproteins in pathogenesis is largely unknown; however, they are hypothesized to be of biological relevance in terms of target cell...

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