Malaria

New findings in the area of malaria described

Published in TB and Outbreaks Week, October 25th, 2005

Investigators in Sweden and the United States have published new malaria data.

Study 1: Potent inhibitors of malarial plasmepsin I and II have been synthesized.

"New and potent inhibitors of the malarial aspartic proteases plasmepsin (Plm) I and II, from the deadliest malaria parasite Plasmodium falciparum, have been synthesized utilizing Suzuki coupling reactions on previously synthesized bromobenzyloxy-substituted statine-like inhibitors.

"The enzyme inhibition activity has been improved up to eight times by identifying P1 substituents that effectively bind to the continuous S1-S3 crevice of Plasmepsin I and II,"...

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Source: TB and Outbreaks Week (2005-10-25)

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