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Mosquito-Borne Disease

Chikungunya virus expressing genes in Aedes mosquitoes characterized

Published in TB and Outbreaks Week, October 25th, 2005

Scientists characterize a double subgenomic chikungunya virus infectious clone to express heterologous genes in Aedes aegypti mosquitoes in a recent issue of Insect Biochemistry and Molecular Biology.

"Three full-length infectious cDNA clones based on the alphavirus chikungunya (CHIKV) were developed and characterized in vitro and in vivo. The full-length clone retained the viral phenotypes of CHIKV in both cell culture and in mosquitoes and should be a valuable tool for the study of virus interactions in an epidemiologically significant natural vector, Aedes aegypti," researchers in the United States report.

"Two additional...

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