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Stem Cell Transplantation

Asymptomatic CMV infection has a negative impact on T-cell proliferation in SCT recipients

Published in TB and Outbreaks Week, November 8th, 2005

Asymptomatic cytomegalovirus infection has a negative impact on T-cell proliferation in allogeneic hematopoietic stem cell transplantation recipients.

According to a recently published study from Poland, "In immune-competent individuals, human cytomegalovirus (HCMV) infection is associated with impairment of T-cell function.

"Our goal was to evaluate prospectively whether clinically asymptomatic HCMV infection in allogeneic hematopoietic stem cell transplantation (alloHSCT) recipients, treated preemptively with ganciclovir, influences T-cell function as well."

"Mitogen-stimulated T-cell proliferative activity, together with cell...

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