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Epidemiology

Molecular typing accurately identifies epidemiological links between TB patients

Published in TB and Outbreaks Week, November 29th, 2005

Molecular typing based on variable numbers of tandem repeats accurately identifies epidemiological links between tuberculosis patients.

"IS6110 fingerprinting of Mycobacterium tuberculosis is the standard identification method in studies on transmission of tuberculosis. However, intensive epidemiological investigation may fail to confirm transmission links between patients clustered by IS6110-restriction fragment length polymorphism (RFLP) typing," scientists writing in the Journal of Clinical Microbiology report.

"We applied typing based on variable numbers of tandem repeats (VNTRs) of mycobacterial interspersed repetitive units...

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