Bacteriology
Mycobacterium smegmatis mycothiol synthase mutant has an altered thiol redox status
Published in TB and Outbreaks Week, January 3rd, 2006
"Mycobacteria and other actinomycetes do not produce glutathione but make mycothiol (MSH; AcCys-GlcN-Ins) that has functions similar to those of glutathione and is essential for growth of Mycobacterium tuberculosis.
"Mycothiol synthase (MshD) catalyzes N acetylation of Cys-GlcN-Ins to produce MSH in Mycobacterium smegmatis mc(2)155, and Cys-GlcN-Ins is maintained at a low level," scientists in the United States report.
According to G.L. Newton and colleagues at the University of California, San Diego, "The mycothiol synthase...
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