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HIV/AIDS Opportunistic Infection
Virulent R. equi suppresses acidification in phagolysosomes to ensure survival
January 17th, 2006
Virulent Rhodococcus equi suppresses acidification in phagolysosomes to ensure survival in the bactericidal environment. According to recent research from Japan, "Rhodococcus equi is one of the most important causes of pneumonia in foals and has emerged as a significant opportunistic pathogen of immunosuppressed hosts such as human immunodeficiency virus-infected patients. "Virulent R. equi harboring an 85 kb plasmid, but not the avirulent form lacking the plasmid, has the ability to survive in macrophages. However, the survival mechanism is not known." "In the present study," wrote K. Toyooka and colleagues...
Source: TB & Outbreaks Week (2006-01-17)
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