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Mycobacterium Bovis BCG
Neutrophil stimulation with M. bovis BCG causes release of functional soluble TRAIL/Apo-2L
January 17th, 2006
Neutrophil stimulation with Mycobacterium bovis BCG causes the release of functional soluble TRAIL/Apo-2L. "Mycobacterium bovis bacillus Calmette-Guerin (BCG) has been used to treat bladder cancer for almost 30 years; however, the effector mechanism of the BCG-induced antitumor response remains enigmatic. "Most BCG research has focused on the mononuclear-cell infiltrate, but growing evidence supports a role for neutrophils in the antitumor response," researchers in the United States report. According to T.J. Kemp and colleagues at the University of Iowa, "Previously, we demonstrated increased urinary tumor necrosis...
Source: TB & Outbreaks Week (2006-01-17)
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