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Sarcoidosis
Endotoxin upregulates interleukin-18 in sarcoidosis
January 17th, 2006
Endotoxin upregulates interleukin-18 in sarcoidosis. "Sarcoidosis is a granulomatous disease of unknown etiology characterized by a helper T-cell type 1-mediated process. Previously we demonstrated a role for interleukin-18 in sarcoidosis. "Here we examine the regulation of interleukin-18 in this condition. Cytokine levels in sarcoid epithelial lining fluid were measured by ELISA," scientists writing in the American Journal of Respiratory and Critical Care Medicine report. "We examined interleukin-18 promoter activity and mRNA and protein levels in the epithelial lining fluid of individuals with active sarcoidosis, and of...
Source: TB & Outbreaks Week (2006-01-17)
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