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West Nile Virus
WNV replication interferes with poly(I:C)-induced IFN gene transcription and IFN response
January 17th, 2006
West Nile virus replication interferes with both poly(I:C)-induced interferon gene transcription and response to interferon therapy. According to researchers in the United States, "West Nile virus (WNV), the leading cause of viral encephalitis in the United States, is an arthropod-transmitted member of the family Flaviviridae. We have explored the interaction of this positive-strand RNA virus with signaling pathways involved in induction of the host's innate immune response." "Phosphorylation of STAT-1 in response to interferon (IFN) treatment and the ability of IFN to establish an antiviral state were reduced in WNV replicon-bearing cell...
Source: TB & Outbreaks Week (2006-01-17)
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