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Tuberculosis Therapy

Gatifloxacin-containing regimen offers potential shorter treatment for TB

Published in TB and Outbreaks Week, February 7th, 2006

Clinical trial results on a new combination treatment that could dramatically shorten the length of tuberculosis (TB) treatment were presented at the recently-held 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy in Washington, DC.

The Phase II trial results of a gatifloxacin-containing regimen are demonstrating good potential. The regimen is significantly more potent than the currently recommended 6-month regimen of isoniazid, rifampicin, pyrazinamide, and ethambutol, and suggests that when gatifloxacin is used instead of ethambutol, the standard 6-month regimen may be shortened to 4 months.

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