Genetics & Genomics
Reports describe recent advances in genetics & genomics research
Published in TB and Outbreaks Week, April 11th, 2006
Study 1: Mycobacterium tuberculosis alpha-crystallin-like hspX gene deletion causes increased bacterial growth.
"Hypervirulent mutants of Mycobacterium tuberculosis, whose growth rates are higher in vivo, have now been reported to have mutations in both regulatory and structural genes, but the basis for this unusual phenotype is not understood.
"One hypervirulence gene, dosR (devR, Rv2031c), activates transcription of approximately 50 genes in this pathogen in response to hypoxia and nitric oxide...
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