Tuberculosis Genetics
Tuberculosis resistance associated with IFN-gamma gene polymorphisms
Published in TB and Outbreaks Week, April 11th, 2006
"We analyzed frequencies of two single-nucleotide polymorphisms (SNP) in the interferon-gamma (IFN-gamma) receptor-1 (IFNGR1) gene promoter (G-611A, T-56C) in tuberculosis patients (n=244) and compared them with controls (n=521).
"These frequencies were not significantly different, whether analysed independently or as haplotypes," scientists in Norway report.
According to L. Bulatkardum and colleagues at the University of Oslo, "Because these SNP affect transcription, the results suggest that the expression of the IFNGR1 gene does not confer...
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