Drug Development
SARS coronavirus infection neutralized by monoclonal antibodies
Published in TB and Outbreaks Week, April 18th, 2006
"We have previously shown that an Escherichia coli-expressed, denatured spike (S) protein fragment of the severe acute respiratory coronavirus, containing residues 1029 to 1192 which include the heptad repeat 2 (HR2) domain, was able to induce neutralizing polyclonal antibodies.
"In this study, monoclonal antibodies (MAbs) were raised against this fragment to identify, the linear neutralizing epitopes in the functional domain and to investigate the mechanisms involved in neutralization," wrote investigators in Singapore.
"Eighteen hybridomas secreting the S...
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