Diagnostics
Filter sterilization of infectious samples may result in false-negative MMP activity
Published in TB and Outbreaks Week, April 25th, 2006
According to recent research published in the Journal of Immunological Methods, "Matrix metalloproteinases (MMPs) are implicated in the immunopathology of numerous infectious diseases.
"High risk samples such as those generated after infection with Mycobacterium tuberculosis require filter sterilization for safe analysis of MMP concentrations. Here, we report that commercial filter membranes may cause artifacts by binding MMPs."
"Anopore 0.2 mcM membrane filtration reduced MMP-1 concentrations to undetectable...
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