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Malaria

Cerebral malaria murine studies improved with SHIRPA screen

Published in TB and Outbreaks Week, May 2nd, 2006

The SHIRPA screening system can facilitate the study of cerebral malaria (CM) in mouse models.

In a recent study from Australia, "different features of sensorimotor function and behavior" were assessed in murine CM and "malaria without cerebral involvement (non-CM) applying the primary screen of the SHIRPA protocol."

"Histopathological analysis of distinct brain regions was performed and the relative size of hemorrhages and plugging of blood cells to brain vasculature was analyzed," explained P. Lackner and coauthors at Innsbruck Medical University.

"Animals suffering from CM develop a wide range of behavioral and functional...

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