Drug Development
Monoclonal antibodies against Nipah virus developed
Published in TB and Outbreaks Week, May 16th, 2006
According to recently published research from Canada, "Nipah virus, a zoonotic paramyxovirus which emerged recently was chemically inactivated using binary ethylenimine (BEI). The inactivated virus was concentrated and purified by sucrose gradient centrifugation.
"The gradient fractions were examined by electron microscopy and Western immunoblot and gradient fraction containing mainly Nipah matrix (M) and nucleocapsid (N) proteins was used for immunizing BALB/c mice, to generate hybridomas."
"Screening of the resultant hybridoma clones identified five strongly positive...
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