Published in TB and Outbreaks Week, June 6th, 2006
"A promising approach to reduce the impact of influenza is the use of an attenuated life virus as a vaccine. Using reverse genetics, a mutant of strain A/WSN/33 with a modified cleavage site within its hemagglutinin was generated which depends on proteolytic activation by elastase," investigators in Germany report.
According to the authors, "Unlike the wild-type requiring trypsin, this mutant is strictly dependent on elastase. Both viruses grow...
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