Antimicrobial Drug Development
Passifloricin analogues have antimalarial and antimycobacterial activity
Published in TB and Outbreaks Week, June 13th, 2006
According to a study from Colombia, "Several structural analogues of the polyketide passifloricin lactone were synthesized using asymmetric stereoselective allylations and ring-closing methateses as key reactions.
"These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis (strain UA 140), trophozoites of Plasinodium falciparum (strain NF54), and Mycobacterium tuberculosis (strain H(37)Rv)."
"However, in spite of the significative antiparasitic activity of some synthetic analogues," wrote W. Cardona...
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