Conjugated Vaccine Development
Method developed for obtaining conjugated vaccines
Published in TB and Outbreaks Week, July 4th, 2006
"We describe a new method to obtain conjugates against Neisseria meningitidis serogroups A, B, C, Vibrio cholera, and Salmonella typhi and their immunogenicity in Balb/c mice.
"The saccharides were activated by basic hydrolysis with the generation of amine groups in the saccharidic chain, and these groups were linked to carboxyl groups of tetanus toxoid by via carbodiimida-mediated reaction," researchers in Cuba report.
According to the authors, "The resultant conjugates were administered to mice for the immunogenicity studies. The pirogenicity...
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