Hepatitis C Virus Pathogenesis
Fas ligand responsible for CXCR3 chemokine induction in CD4 cell-dependent liver damage
Published in TB and Outbreaks Week, July 18th, 2006
According to a study from the United States, "Immune-mediated hepatic damage has been demonstrated in the pathogenesis of hepatitis C virus (HCV) and other hepatotrophic infections. Fas/Fas ligand (FasL) interaction plays a critical role in immune-mediated hepatic damage.
"To understand the molecular mechanism(s) of FasL-mediated liver inflammation, we examined the effect of CD4+ T cells expressing high levels of FasL on the initiation of hepatic damage through analysis of chemokine and chemokine receptor expression in HCV core x TCR (DO11.10)...
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