Antituberculosis Drug Development
Mycobacterium tuberculosis inhibited by gatifloxacin derivatives
Published in TB and Outbreaks Week, July 18th, 2006
"Sixteen 7-substituted gatifloxacin derivatives were synthesized and evaluated for antimycobacterial activity in vitro and in vivo against Mycobacterium tuberculosis H37Rv (MTB) and multidrug resistant M. tuberculosis (MDR-TB), and also tested for the ability to inhibit the supercoiling activity of DNA gyrase from M. tuberculosis.
"Among the synthesized compounds, 1-cyclopropyl-6-fluoro-8-methoxy-7-[ N-4-[I'-(5-isatinyl-beta-semicarbazo)]methyl]3-methyl]N-1-piperazinyl]-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (3d) was found to be the most...
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