Infectious Diseases
Plasmodium falciparum membrane proteins are refractory to genetic deletion
Published in TB and Outbreaks Week, August 29th, 2006
"Targeted gene disruption has proved to be a powerful approach for studying the function of important ligands involved in erythrocyte invasion by the extracellular merozoite form of the human malaria parasite, P. falciparum. Merozoite invasion proceeds via a number of seemingly independent alternate pathways, such that entry can proceed with parasites lacking particular ligand-receptor interactions.
"To date, most focus in this regard has been on single-pass (type 1) membrane...
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