Drug Development
Reports from India, the United Kingdom and Mexico advance knowledge in drug development research
Published in TB and Outbreaks Week, August 29th, 2006
Study 1: Gatifloxacin derivatives inhibit Mycobacterium tuberculosis DNA gyrase.
"Sixteen 7-substituted gatifloxacin derivatives were synthesized and evaluated for antimycobacterial activity in vitro and in vivo against Mycobacterium tuberculosis H37Rv (MTB) and multidrug resistant M. tuberculosis (MDR-TB), and also tested for the ability to inhibit the supercoiling activity of DNA gyrase from M. tuberculosis.
"Among the synthesized compounds, 1-cyclopropyl-6-fluoro-8-methoxy-7-[...
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