Antimicrobials
Bisbenzamidine derivatives active against Pneumocystis pneumonia and less toxic than pentamidine
Published in TB and Outbreaks Week, August 29th, 2006
According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host.
"To identify potential anti-Pneumocystis agents, we synthesized bisbenzamidine derivatives in which the parent compound pentamidine was modified by a 1,4-piperazinediyl, alkanediamide, or 1,3-phenylenediamide moiety as the central linker."
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