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Antituberculosis Toxicity

Hepatotoxicity self-limiting after short-course therapy for latent tuberculosis

Published in TB and Outbreaks Week, August 29th, 2006

Hepatotoxicity is self-limiting following short-course therapy in patients with latent tuberculosis.

"Nine months of isoniazid therapy is the recommended regimen for treatment of latent tuberculosis infection, but low completion rates are a serious problem. The search for shorter regimens, compared with the standard isoniazid regimen, is of vital importance.

"We describe our experience using short-course regimens for the treatment of latent tuberculosis infection. We conducted a nonrandomized, observational study of 459 patients in a county health department from June 2000 to January 2006," researchers in the United States report.

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